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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DKC1
All Species:
12.42
Human Site:
T458
Identified Species:
19.52
UniProt:
O60832
Number Species:
14
Phosphosite Substitution
Charge Score:
0.29
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O60832
NP_001354.1
514
57674
T458
S
E
S
E
S
D
E
T
P
P
A
A
P
Q
L
Chimpanzee
Pan troglodytes
XP_521345
595
65925
T539
S
E
S
E
S
D
E
T
P
P
A
A
P
Q
L
Rhesus Macaque
Macaca mulatta
XP_001090867
597
66468
T541
S
E
S
E
S
D
E
T
P
P
A
A
P
Q
L
Dog
Lupus familis
XP_549382
517
57997
E462
P
K
R
K
R
D
S
E
S
D
E
L
S
P
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q9ESX5
509
57483
E454
R
K
R
D
S
E
S
E
S
D
E
T
P
T
V
Rat
Rattus norvegicus
P40615
509
56597
D453
V
K
R
K
R
D
S
D
S
D
A
D
E
A
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514686
519
58453
V464
E
A
A
P
S
S
P
V
T
P
K
S
E
E
M
Chicken
Gallus gallus
Q5ZJH9
516
58132
A459
V
S
P
P
P
S
P
A
T
P
P
P
E
E
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001028279
506
56658
T450
A
A
Q
D
T
S
K
T
E
E
E
S
K
K
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O44081
508
56812
A450
T
S
S
V
E
E
T
A
A
A
A
V
S
E
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O17919
445
50192
K391
G
L
L
D
K
F
G
K
P
N
D
T
T
P
K
Sea Urchin
Strong. purpuratus
XP_001187533
541
60439
E479
A
E
A
V
E
E
E
E
E
M
E
T
S
V
V
Poplar Tree
Populus trichocarpa
XP_002323264
482
54054
S428
E
P
V
K
K
K
K
S
K
E
D
A
E
V
E
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LD90
565
63008
E508
K
K
K
D
K
K
E
E
V
I
E
E
V
A
S
Baker's Yeast
Sacchar. cerevisiae
P33322
483
54686
V421
E
D
S
L
I
K
E
V
E
T
E
K
E
E
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.3
85.5
89.9
N.A.
90
83.2
N.A.
85.3
81.4
N.A.
74.7
N.A.
64.7
N.A.
58.7
64.8
Protein Similarity:
100
85.3
86
93.6
N.A.
93.1
90.8
N.A.
88.8
89.9
N.A.
85.4
N.A.
77.6
N.A.
71.4
77
P-Site Identity:
100
100
100
6.6
N.A.
13.3
13.3
N.A.
13.3
13.3
N.A.
6.6
N.A.
13.3
N.A.
6.6
13.3
P-Site Similarity:
100
100
100
20
N.A.
40
26.6
N.A.
40
20
N.A.
46.6
N.A.
33.3
N.A.
13.3
40
Percent
Protein Identity:
61.2
N.A.
N.A.
57.5
57.9
N.A.
Protein Similarity:
76.4
N.A.
N.A.
73.4
71.9
N.A.
P-Site Identity:
6.6
N.A.
N.A.
6.6
13.3
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
20
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
14
14
14
0
0
0
0
14
7
7
34
27
0
14
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
7
0
27
0
34
0
7
0
20
14
7
0
0
0
% D
% Glu:
20
27
0
20
14
20
40
27
20
14
40
7
34
27
20
% E
% Phe:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% F
% Gly:
7
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
7
0
0
0
0
7
0
0
0
0
0
% I
% Lys:
7
27
7
20
20
20
14
7
7
0
7
7
7
7
7
% K
% Leu:
0
7
7
7
0
0
0
0
0
0
0
7
0
0
27
% L
% Met:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
7
% M
% Asn:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% N
% Pro:
7
7
7
14
7
0
14
0
27
34
7
7
27
14
0
% P
% Gln:
0
0
7
0
0
0
0
0
0
0
0
0
0
20
7
% Q
% Arg:
7
0
20
0
14
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
20
14
34
0
34
20
20
7
20
0
0
14
20
0
7
% S
% Thr:
7
0
0
0
7
0
7
27
14
7
0
20
7
7
7
% T
% Val:
14
0
7
14
0
0
0
14
7
0
0
7
7
14
20
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _